Despite the roller coaster ride at the end of November, both the Biotech Daily Top-40 Index (BDI-40) and the three Big Caps closed the month just below their record highs.

The benchmark ASX200 fell 0.9 percent and the Nasdaq Biotechnology Index (NBI) fell 4.0 percent.

The collective market capitalization of the three Big Caps of Cochlear, CSL and Resmed (which are not included in the BDI-40) climbed 0.6 percent in November to $206,981 million, propped-up by CSL climbing 2.3 percent to $139,795 million, while Cochlear fell 4.4 percent to $14,326 million and Resmed was down 2.4 percent to $52,860 million.

For the year to November 30, the BDI-40 climbed 24.6 percent, the ASX200 was up 11.3 percent, the Big Caps rose 17.5 percent and the NBI was up 5.2 percent. The 22 companies in Cannabis Corner were up 33.9 percent for the year (see below).

November showed the value of a diverse portfolio. While Cochlear and Resmed fell, CSL held up the Three Big Caps.

Just 10 of the BDI-40 companies were up, with five up by more than 10 percent, while 29 fell, five by more than 20 percent and 13 by more than 10 percent.

But a 14.3 percent increase by Pro Medicus to $6,522 million and Imugene up 14.9 percent to $3,139 million counter-balanced all the large, modest and small falls.

Universal Biosensors was November’s best, up 18.9 percent to $157 million, followed by Imugene and Proteomics, both up 14.9 percent, followed by Pro Medicus (14.3%), Telix (11.1%), Impedimed (9.0%), Amplia (8.0%), Paradigm (7.7%), Mesoblast (7.0%) and Starpharma (1.4%).

Clinuvel led the falls from a near record high, down $483 million or 25.4 percent to $1,422 million, followed by Osprey (24.0%), Polynovo (22.5%), Ellex (21.7%), Antisense (20.1%), LBT (18.1%), Immutep (16.6%), Cynata (14.8%), Alterity (14.3%), Prescient (13.3%), Optiscan (12.3%), Compumedics (11.6%) and Avita (11.5%).

Outside the BDI-40, Aroa Biosurgery and Rhythm Biosciences were at 12-month highs, with IDT, Micro-X, Race Oncology and Trajan holding steady.

The collective market capitalization of the 22 companies in Cannabis Corner was up 7.5 percent in November to $1,941 million, with just five up, 14 down and three unchanged; but Incannex added $200 million or 40.9 percent to $689 million, with Cronos jumping $19 million or 237.5 percent and Emyria up $42 million or 110.5 percent - countering all the falls.

On the Nasdaq, Eyepoint (formerly Psivida) climbed 71.3 percent to $752 million, Queensland’s Protagonist was up 14.3 percent to $2,252 million, but Redhill, with Australian assets, lost 37.6 percent to $211 million.